Endocrine Abstracts

Worldwide, breast cancer is the most common cancer to develop in women. Steroid receptors play a key role in the progression of the majority of breast cancer subtypes. Estrogen Receptor-α (ERα), for example drives the growth of approximately 70% of tumours and is therefore a useful therapeutic target for this disease. However, the Androgen Receptor (AR) is the highest expressed receptor in normal breast and appears to also play an important role in breast cancer. In ...

Prostate cancer is currently treated with hormonal therapies, which aim to block the production and/or action of androgens. However, tumours eventually progress to castration-resistant prostate cancer and there is a great need for new therapeutic approaches. We have designed and tested engineered repressors which could be effective in circumstances where current therapies fail. These consist of two modules: an interaction domain, which binds directly to the androgen receptor (...